转录激活蛋白crsp70抗体

英文名称 APC70
中文名称 转录激活蛋白crsp70抗体
别    名 Transcriptional coactivator CRSP70; ctivator recruited cofactor 70 kDa component; Activator-recruited cofactor 70 kDa component ; ARC 70 ; ARC70; Cofactor required for Sp1 transcriptional activation subunit 7; CRSP 7; CRSP complex subunit 7; MED 26; MED26; MED26_HUMAN; Mediator complex subunit 26; Mediator of RNA polymerase II transcription subunit 26.
转录激活蛋白crsp70抗体
说 明 书 0.2ml  
研究领域 细胞生物  染色质和核信号  神经生物学  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 66kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CRSP70
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Subunit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the Mediator complex subunit 26 family.
Contains 1 TFIIS N-terminal domain.

Gene ID:
9441

Database links:

Entrez Gene: 9441 Human

Entrez Gene: 70625 Mouse

Omim: 605043 Human

SwissProt: O95402 Human

SwissProt: Q7TN02 Mouse

SwissProt: Q8BUP9 Mouse

Unigene: 356467 Human

Unigene: 729178 Human

Unigene: 235885 Mouse

Unigene: 440960 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

xy-15496R ALDH3A1乙醛脱氢酶家族3成员A1抗体
xy-12963R phospho-alpha B Crystallin (Ser59)磷酸化热休克蛋白β5/αb晶体蛋白质/α-晶体蛋白b链抗体
xy-12368R ACTG2γ2肌动蛋白抗体
xy-12392R AESgp130结合蛋白GAM抗体
xy-12414R AMHR2缪勒激素2型受体抗体
xy-12415R ACTR1激活素受体1A抗体
xy-12416R ACTR2激活素受体2A抗体
xy-12417R Activin Receptor Type IIB激活素受体2B抗体
xy-15163R C2orf88 2号染色体开放阅读框88抗体
xy-7144R ARHGEF18G蛋白偶联受体ARHGEF18抗体
xy-3763R Activin A Receptor Type IB激活素受体1B抗体
xy-3751R ARA24雄激素受体相关蛋白24抗体
xy-0347R Amyloid Precursor Protein淀粉样肽前体蛋白抗体（C端）
xy-3920R ADCY2腺苷酸环化酶2抗体
xy-5037R APOC3载脂蛋白C3抗体
xy-5038R Apolipoprotein E4载脂蛋白E4抗体
xy-3830R AMBRA1自噬相关基因AMBRA1抗体
xy-5200R Phospho-ATG4C(Ser177)磷酸化自噬相关蛋白4C抗体
xy-5205R Phospho-ATG4C(Ser398)磷酸化自噬相关蛋白4C抗体
xy-3007R phospho-ASK1 (Ser966)磷酸化细胞凋亡信号调节激酶1抗体
xy-3008R phospho-ATXN1 (Ser775)磷酸化失调症蛋白1抗体
xy-2732R ATXN1/Ataxin-1脊髓小脑失调症蛋白1抗体
xy-3028R phospho-Amyloid Precursor Protein (Thr668)磷酸化APP淀粉样肽前体蛋白抗体
xy-3029R phospho-ASK1 (Ser967)磷酸化细胞凋亡信号调节激酶1抗体