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B-细胞淋巴瘤因子6(Bcl6)重组蛋白 转录抑制因子主要用于生发中心(GC)的形成和抗体亲和力的成熟,其作用机制与谱系和生物学功能有关。在基因毒性应激中,p53/TP53依赖性和非依赖性控制GC B细胞的细胞周期阻滞。此外,还可以通过改变选择性NOTCH靶点(如HES5)的NOTCH依赖性转录复合物的组成来控制神经发生,包括去乙酰化酶SIRT1的募集,并导致表观遗传沉默,神经元分化。
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品牌 | 上海信裕生物科技有限公司 | CAS | 详见说明书 |
---|---|---|---|
分子式 | 详见说明书 | 纯度 | >95% |
分子量 | 49.1kDa | 货号 | XY90567RPHu |
规格 | 50µg/100µg | 供货周期 | 一周 |
主要用途 | SDS-PAGE; WB | 应用领域 | 生物产业 |
Recombinant B-Cell CLL/Lymphoma 6 (Bcl6)
B-细胞淋巴瘤因子6(Bcl6)重组蛋白
[ PROPERTIES ]
Source: Prokaryotic expression
Host: E.coli
Residues: Met1~Tyr408
Tags: N-terminal His Tag
Subcellular Location: Nucleus
Purity: > 95%
Traits: Freeze-dried powder
Buffer formulation: PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Original Concentration: 200µg/mL
Applications: Positive Control; Immunogen; SDS-PAGE; WB.
(May be suitable for use in other assays to be determined by the end user.)
Predicted isoelectric point: 6.2
Predicted Molecular Mass: 49.1kDa
Accurate Molecular Mass: 49kDa as determined by SDS-PAGE reducing conditions.
[ USAGE ]
Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
[ STORAGE AND STABILITY ]
Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8ºC for one month.
Aliquot and store at -80ºC for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
[SEQUENCE ]
[ IDENTIFICATION ]
[ IMPORTANT NOTE ]
The kit is designed for research use only, we will not be responsible for any issue if the kit was used in clinical diagnostic or any other procedures.
特别提示:本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!以实际收货产品说明书为准,网站说明书仅供参考!
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