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APBA2抗原;APBA2重组蛋白多种属 β-淀粉样前体蛋白(β-APP)是阿尔茨海默病患者淀粉样沉积物的主要成分。已知β-淀粉样蛋白前体与几种蛋白质相互作用,包括X11和G异养蛋白APP-BP1。已知神经元跨膜蛋白X11通过磷酸酪氨酸结合(PTB)结构域与∫-淀粉样前体蛋白结合,减少细胞βAPP的分泌,减缓βAPP的加工途径。X11特异性结合YENPTY基序,该基序参与Beta APP的内化。X
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品牌 | 信裕生物 | CAS | 详见说明书 |
---|---|---|---|
分子式 | 详见说明书 | 纯度 | > 90% |
分子量 | 33.0kDa | 货号 | XY90313RPHu |
规格 | 50µg/100µg | 供货周期 | 一周 |
主要用途 | SDS-PAGE; WB; ELISA; IP. | 应用领域 | 生物产业 |
Recombinant Amyloid Beta Precursor Protein Binding Protein A2 (APBA2)
淀粉样蛋白β前体蛋白结合蛋白A2(APBA2)重组蛋白
[ PROPERTIES ]
Residues: Tyr459~Asn722,with two N-terminal Tags, His-tag and T7-tag.
Host: E. coli
Subcellular Location: Membrane; Multi-passmembrane protein.
Purity: >95%
Endotoxin Level: <1.0EU per 1μg
(determined by the LAL method).
Formulation: Supplied as lyophilized form in PBS,pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Predicted isoelectric point: 7.7
Predicted Molecular Mass: 32.5kDaApplications: SDS-PAGE; WB; ELISA; IP
(May be suitable for use in other assays to be determined by the end user.)
[ USAGE ]
Reconstitute in sterile PBS, pH7.2-pH7.4.
[ STORAGE AND STABILITY ]
Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8ºC for one month.
Aliquot and store at -80ºC for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
[SEQUENCE ]
The target protein is fused with two N-terminal Tags, His-tag and T7-tag, itssequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- YI ADIGNIVVLMARRRMPRSASQDCIETTPGA QEGKKQYKMI CHVFESEDAQ LIAQSIGQAF SVAYQEFLRA NGINPEDLSQKEYSDIINTQ EMYNDDLIHF SNSENCKELQ LEKHKGEILG VVVVESGWGS ILPTVILANMMNGGPAARSG KLSIGDQIMS INGTSLVGLP LATCQGIIKG LKNQTQVKLN IVSCPPVTTVLIKRPDLKYQ LGFSVQNGII CSLMRGGIAE RGGVRVGHRI IEINGQSVVA TAHEKIVQALSN
[ IDENTIFICATION ]
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