Articles
CYLD抗原;圆柱瘤蛋白(CYLD)重组蛋白多种属 CYLD(cylindromatosis)是近年发现的一种肿瘤抑制基因,CYLD丢失或突变可致肿瘤形成,多个研究显示,其表达蛋白CYLD可去泛素化TRAFs、NEMO、Bcl-3及p53等信号分子,调控细胞NF-κB和JNK等信号途径,CYLD在人体内广泛分布,在细胞周期的调控、介导细胞凋亡、抑制肿瘤发生等分子事件中有着重要的调控作用。
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品牌 | 上海信裕生物科技有限公司 | CAS | 详见说明书 |
---|---|---|---|
分子式 | 详见说明书 | 纯度 | > 95% |
分子量 | 22.1kDa | 货号 | XY91342RPHu |
规格 | 50µg/100µg | 供货周期 | 一周 |
主要用途 | SDS-PAGE; WB; ELISA; IP. | 应用领域 | 生物产业 |
Recombinant Cylindromatosis (CYLD)
圆柱瘤蛋白(CYLD)重组蛋白
[ PROPERTIES ]
Residues: Glu170~Gly338,with two N-terminal Tags, His-tag and T7-tag.
Host: E. coli
Subcellular Location: Cytoplasm, perinuclearregion. Cytoskeleton. Cell membrane; Peripheralmembrane protein; Cytoplasmic side.
Purity: >95%
Endotoxin Level: <1.0EU per 1μg(determined by the LAL method).
Formulation: Supplied as lyophilized form in PBS,pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Predicted isoelectric point: 4.9
Predicted Molecular Mass: 22.1kDa
Applications: SDS-PAGE; WB; ELISA; IP.
(May be suitable for use in other assays to be determined by the end user.)
[ USAGE ]
Reconstitute in sterile PBS, pH7.2-pH7.4.
[ STORAGE AND STABILITY ]
Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8ºC for one month.
Aliquot and store at -80ºC for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
[SEQUENCE ]
The target protein is fused with two N-terminal Tags, His-tag and T7-tag, itssequence is listed below.
MGSS H H H H H H SS G LV P R GS H MASM T G G Q QM GRGS E F - E GR G Q G F T D GVYQGKQLFQCD EDCGVFVALD KLELIEDDDT ALESDYAGPG DTMQVELPPL EINSRVSLKVGETIESGTVI FCDVLPGKES LGYFVGVDMD NPIGNWDGRF DGVQLCSFACVESTILLHINDIIPESVTQE RRPPKLAFMS RGVGDKGSSS HNKPKATG
[ IDENTIFICATION ]
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